Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging.

ABSTRACT: A kind of fluorescent/phosphorescent dual-emissive conjugated polyelectrolyte has been prepared by introducing phosphorescent platinum(ii) porphyrin (O₂-sensitive) into a fluorene-based conjugated polyelectrolyte (O₂-insensitive), which can form ultrasmall conjugated polymer dots (FP-Pdots) in the phosphate buffer solution (PBS) via self-assembly caused by their amphiphilic structures with hydrophobic backbones and hydrophilic side chains. These FP-Pdots can exhibit an excellent ratiometric luminescence response to O₂ content with high reliability and full reversibility for measuring oxygen levels, and the excellent intracellular ratiometric O₂ sensing properties of the FP-Pdots nanoprobe have also been confirmed by the evident change in t

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC5485888 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature