Low-level inorganic arsenic exposure and neuropsychological functioning in American Indian elders.

ABSTRACT:

Background

Inorganic arsenic at high and prolonged doses is highly neurotoxic. Few studies have evaluated whether long-term, low-level arsenic exposure is associated with neuropsychological functioning in adults.

Objectives

To investigate the association between long-term, low-level inorganic arsenic exposure and neuropsychological functioning among American Indians aged 64-95.

Methods

We assessed 928 participants in the Strong Heart Study by using data on arsenic species in urine samples collected at baseline (1989-1991) and results of standardized tests of global cognition, executive functioning, verbal learning and memory, fine motor functioning, and speed of mental processing administered during comprehensive follow-up evaluations in 2009-2013. We calculated the d

SUBMITTER: Carroll CR 

PROVIDER: S-EPMC5485900 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature