Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) shows a substantial clinical heterogeneity. The existing risk classification for PCa prognosis based on clinical factors is not sufficient. Although some biomarkers for PCa aggressiveness have been identified, their underlying functional mechanisms are still unclear. We previously reported a gene-gene interaction network associated with PCa aggressiveness based on single nucleotide polymorphism (SNP)-SNP interactions in the angiogenesis pathway. The goal of this study is to investigate potential functional evidence of the involvement of the genes in this gene-gene interaction network.

Methods

A total of 11 angiogenesis genes were evaluated. The crosstalks among genes were examined through coexpression and expression quantitative trait loci (e

SUBMITTER: Lin HY 

PROVIDER: S-EPMC5485921 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature