Interactions between a Heparin Trisaccharide Library and FGF-1 Analyzed by NMR Methods.

ABSTRACT: FGF-1 is a potent mitogen that, by interacting simultaneously with Heparan Sulfate Glycosaminoglycan HSGAG and the extracellular domains of its membrane receptor (FGFR), generates an intracellular signal that finally leads to cell division. The overall structure of the ternary complex Heparin:FGF-1:FGFR has been finally elucidated after some controversy and the interactions within the ternary complex have been deeply described. However, since the structure of the ternary complex was described, not much attention has been given to the molecular basis of the interaction between FGF-1 and the HSGAG. It is known that within the complex, the carbohydrate maintains the same helical structure of free heparin that leads to sulfate groups directed towards opposite directions along the molecular axi

SUBMITTER: Garcia-Jimenez MJ 

PROVIDER: S-EPMC5486114 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature