Immune classifications with cytotoxic CD8⁺ and Th17 infiltrates are predictors of clinical prognosis in glioblastoma.

ABSTRACT:

Background

Interest is growing on immune cells involvement in central nervous system tumors such as glioblastoma. Even if a few reports highlighted that immune classifications could have a prognostic value, no paradigm has been clearly yet established on large and homogeneous cohorts. The aim of our study was to analyze the prognostic role of the in situ immune response of cytotoxic T cells (i.e., CD8⁺), Foxp3 cells, Th17 and tumor-associated macrophages in glioblastoma on two independent large and homogeneous cohorts.

Methods

We worked on two large homogenous cohorts of patients having glioblastoma who underwent standard radiochemotherapy. The first cohort of 186 patients was analyzed using IHC procedures (CD8⁺, IL-17A, FoxP3 and CD163) of surgery piec

SUBMITTER: Madkouri R 

PROVIDER: S-EPMC5486170 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature