Cytokine gene associations with self-report ratings of morning and evening fatigue in oncology patients and their family caregivers.

ABSTRACT: The purpose of this study was to evaluate for differences in variations in pro- and anti-inflammatory cytokine genes between participants who were classified as having low and high levels of morning and evening fatigue and to evaluate for differences in phenotypic characteristics between these two groups. In a sample of 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their family caregivers, growth mixture modeling was used to identify latent classes of individuals based on ratings of morning and evening fatigue obtained prior to, during, and for 4 months following completion of radiation therapy. Differences in single nucleotide polymorphisms and haplotypes in 15 cytokine genes were evaluated between the latent classes. Multiple logistic regression was used

SUBMITTER: Dhruva A 

PROVIDER: S-EPMC5486216 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature