Practical calculation method to estimate the absolute boron concentration in tissues using ¹⁸F-FBPA PET.

ABSTRACT:

Purpose

The purpose of this study was to establish a practical method to estimate the absolute boron concentrations in the tissues based on the standardized uptake values (SUVs) after administration of 4-borono-phenylalanine (BPA) using 4-borono-2-¹⁸F-fluoro-phenylalanine (¹⁸F-FBPA) PET.

Methods

Rat xenograft models of C6 glioma (n = 7, body weight 241 ± 28.0 g) were used for the study. PET was performed 60 min after intravenous injection of ¹⁸F-FBPA (30.5 ± 0.7 MBq). After the PET scanning, BPA-fructose (167.3 ± 18.65 mg/kg) was administered by slow intravenous injection to the same subjects. The rats were killed 60 min after the BPA injection and tissue samples were collected from the major organs and tumors. The absolute boron concentratio

SUBMITTER: Watabe T 

PROVIDER: S-EPMC5486508 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature