Comparative evaluation of the algorithms for parametric mapping of the novel myocardial PET imaging agent ¹⁸F-FPTP.

ABSTRACT:

Objective

(¹⁸F-fluoropentyl)triphenylphosphonium salt (¹⁸F-FPTP) is a new promising myocardial PET imaging tracer. It shows high accumulation in cardiomyocytes and rapid clearance from liver. We performed compartmental analysis of ¹⁸F-FPTP PET images in rat and evaluated two linear analyses: linear least-squares (LLS) and a basis function method (BFM) for generating parametric images. The minimum dynamic scan duration for kinetic analysis was also investigated and computer simulation undertaken.

Methods

¹⁸F-FPTP dynamic PET (18 min) and CT images were acquired from rats with myocardial infarction (MI) (n = 12). Regions of interest (ROIs) were on the left ventricle, normal myocardium, and MI region. Two-compartment (K ₁ a

SUBMITTER: Kim JW 

PROVIDER: S-EPMC5486518 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature