Advanced Neuroimaging of Cerebral Small Vessel Disease.

ABSTRACT:

Opinion statement

Cerebral small vessel disease (SVD) is characterised by damage to deep grey and white matter structures of the brain and is responsible for a diverse range of clinical problems that include stroke and dementia. In this review, we describe advances in neuroimaging published since January 2015, mainly with magnetic resonance imaging (MRI), that, in general, are improving quantification, observation and investigation of SVD focussing on three areas: quantifying the total SVD burden, imaging brain microstructural integrity and imaging vascular malfunction. Methods to capture 'whole brain SVD burden' across the spectrum of SVD imaging changes will be useful for patient stratification in clinical trials, an approach that we are already testing. More sophisticated imagin

SUBMITTER: Blair GW 

PROVIDER: S-EPMC5486578 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature