Hepatocellular Carcinoma in Children and Adolescents: Clinical Characteristics and Treatment.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) occurs rarely in children and adolescents (C&A), and its clinical characteristics, prognostic factors, and treatment were rarely explored.

Methods

This retrospective study focused on 65 HCC patients aged ≤20 years from August 1994 to August 2012. Cox regression models and Kaplan-Meier curves were used to investigate prognostic factors and compare overall survival (OS), respectively.

Results

We found 61.5% of patients to have multiple tumors, 30.8% to have portal vein tumor thrombus, and 16.9% to have distant metastasis. Diameter of tumors was 10.2 ± 4.1 cm. OS at 5 years was 15.8%. Multivariate analyses showed initial treatment (P < 0.001) to be a predictor for OS. For moderate-stage HCC, the median OS of patients who underwen

SUBMITTER: Wang J 

PROVIDER: S-EPMC5486687 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature