Assessment of early treatment response to neoadjuvant chemotherapy in breast cancer using non-mono-exponential diffusion models: a feasibility study comparing the baseline and mid-treatment MRI examinations.

ABSTRACT:

Objectives

To assess the feasibility of the mono-exponential, bi-exponential and stretched-exponential models in evaluating response of breast tumours to neoadjuvant chemotherapy (NACT) at 3 T.

Methods

Thirty-six female patients (median age 53, range 32-75 years) with invasive breast cancer undergoing NACT were enrolled for diffusion-weighted MRI (DW-MRI) prior to the start of treatment. For assessment of early response, changes in parameters were evaluated on mid-treatment MRI in 22 patients. DW-MRI was performed using eight b values (0, 30, 60, 90, 120, 300, 600, 900 s/mm²). Apparent diffusion coefficient (ADC), tissue diffusion coefficient (D _t), vascular fraction (ƒ), distributed diffusion coefficient (DDC) and alpha (α) parameters were derived. The

SUBMITTER: Bedair R 

PROVIDER: S-EPMC5486805 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature