Intra-image referencing for simplified assessment of HER2-expression in breast cancer metastases using the Affibody molecule ABY-025 with PET and SPECT.

ABSTRACT:

Purpose

In phase I/II-studies radiolabelled ABY-025 Affibody molecules identified human epidermal growth factor receptor 2 (HER2) expression in breast cancer metastases using PET and SPECT imaging. Here, we wanted to investigate the utility of a simple intra-image normalization using tumour-to-reference tissue-ratio (T/R) as a HER2 status discrimination strategy to overcome potential issues related to cross-calibration of scanning devices.

Methods

Twenty-three women with pre-diagnosed HER2-positive/negative metastasized breast cancer were scanned with [¹¹¹In]-ABY-025 SPECT/CT (n = 7) or [⁶⁸Ga]-ABY-025 PET/CT (n = 16). Uptake was measured in all metastases and in normal spleen, lung, liver, muscle, and blood pool. Normal tissue uptake variation and T/R-r

SUBMITTER: Sandberg D 

PROVIDER: S-EPMC5486836 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature