Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life.

ABSTRACT:

Purpose

Increased visceral adiposity (visceral obesity) and muscle wasting (sarcopenia) at colorectal cancer (CRC) diagnosis, quantified by computed tomography (CT) image analysis, have been unfavorably associated with short-term clinical outcomes and survival, but associations with long-term health-related quality of life (HRQoL) have not been investigated. We studied associations of visceral adiposity, muscle fat infiltration, muscle mass, and sarcopenia at CRC diagnosis with HRQoL 2-10 years post-diagnosis.

Methods

A cross-sectional study was conducted in 104 stage I‒III CRC survivors, diagnosed at Maastricht University Medical Center+, the Netherlands (2002-2010). Diagnostic CT images at the level of the third lumbar vertebra were analyzed to retrospectively determine vi

SUBMITTER: van Roekel EH 

PROVIDER: S-EPMC5486890 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature