Impaired suppression of delay-period alpha and beta is associated with impaired working memory in schizophrenia.

ABSTRACT:

Background

Although people with schizophrenia (PSZ) frequently exhibit reduced working memory capacity relative to healthy comparison subjects (HCS), the mechanisms that underlie this impairment are not yet known. The present study aimed to assess one putative mechanism: impaired suppression of alpha and beta frequency bands during the delay period of a visual working memory task.

Methods

The electroencephalogram (EEG) was recorded from 30 PSZ and 31 HCS while they completed a change detection task in which they were required to remember a briefly presented array of colored squares over an 1800-ms delay interval.

Results

Overall, we found that PSZ had significantly reduced alpha and beta-band suppression during the delay interval compared to HCS, and that these signif

SUBMITTER: Erickson MA 

PROVIDER: S-EPMC5487003 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature