Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection.

ABSTRACT: Mitochondrial dysfunction is a hallmark of many diseases. The retrograde signaling initiated by dysfunctional mitochondria can bring about global changes in gene expression that alters cell morphology and function. Typically, this is attributed to disruption of important mitochondrial functions, such as ATP production, integration of metabolism, calcium homeostasis and regulation of apoptosis. Recent studies showed that in addition to these factors, mitochondrial dynamics might play an important role in stress signaling. Normal mitochondria are highly dynamic organelles whose size, shape and network are controlled by cell physiology. Defective mitochondrial dynamics play important roles in human diseases. Mitochondrial DNA defects and defective mitochondrial function have been reported in

SUBMITTER: Srinivasan S 

PROVIDER: S-EPMC5487289 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature