Association between hormone replacement therapy and subsequent stroke: a meta-analysis.

ABSTRACT:

Objectives

To review completed trials assessing effect of hormone replacement therapy on subsequent risk of stroke, assessing stroke by pathological type, severity, and outcome.

Design

Systematic review of randomised controlled trials identified from the Cochrane Library, Embase, and Medline; reviews; and reference lists of relevant papers.

Studies reviewed

28 trials, with 39 769 subjects, were identified. REVIEW MEASURES: Rates for cerebrovascular events analysed with a random effects model. Sensitivity analyses for heterogeneity included phase of prevention (primary or secondary), type of hormone replacement therapy (oestrogen alone or combined with progesterone), type of oestrogen (estradiol or conjugated equine oestrogen), size of trial (< 5000 or > 5000 patients)

SUBMITTER: Bath PM 

PROVIDER: S-EPMC548730 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature