Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment.

ABSTRACT: Sepsis is a serious clinical problem. Negative regulation of innate immunity is associated with sepsis progression, but the underlying mechanisms remains unclear. Here we show that the receptor CD300f promotes disease progression in sepsis. CD300f ^-/- mice were protected from death after cecal ligation and puncture (CLP), a murine model of septic peritonitis. CD300f was highly expressed in mast cells and recruited neutrophils in the peritoneal cavity. Analysis of mice (e.g., mast cell-deficient mice) receiving transplants of wild-type or CD300f ^-/- mast cells or neutrophils indicated that CD300f deficiency did not influence intrinsic migratory abilities of neutrophils, but enhanced neutrophil chemoattractant production (from mast cells and neutrophils) in the peritone

SUBMITTER: Izawa K 

PROVIDER: S-EPMC5487349 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature