Burn Serum Increases Staphylococcus aureus Biofilm Formation via Oxidative Stress.

ABSTRACT: Staphylococcus aureus is a common pathogen isolated from burn patients that can form biofilms on burn wounds and implanted deep vein catheters, which often leads to refractory infections or even biofilm-related sepsis. As biofilm formation is usually regulated by environmental conditions, we hypothesized that serum composition may be altered after burn injury, potentially affecting the ability of infecting bacteria to form biofilms. As predicted, we observed that serum from burn-injured rats increases biofilm formation by S. aureus and also induces bacterial aggregation and adherence to human fibronectin and fibrinogen. Analysis of potential regulatory factors revealed that exposure to burn serum decreases expression of the quorum-sensing agr system and increases mRNA

SUBMITTER: Yin S 

PROVIDER: S-EPMC5487419 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature