Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways.

ABSTRACT:

Aim

To study the molecular mechanisms involved in the hepatoprotective effects of naringenin (NAR) on carbon tetrachloride (CCl₄)-induced liver fibrosis.

Methods

Thirty-two male Wistar rats (120-150 g) were randomly divided into four groups: (1) a control group (n = 8) that received 0.7% carboxy methyl-cellulose (NAR vehicle) 1 mL/daily p.o.; (2) a CCl₄ group (n = 8) that received 400 mg of CCl₄/kg body weight i.p. 3 times a week for 8 wk; (3) a CCl₄ + NAR (n = 8) group that received 400 mg of CCl₄/kg body weight i.p. 3 times a week for 8 wk and 100 mg of NAR/kg body weight daily for 8 wk p.o.; and (4) an NAR group (n = 8) that received 100 mg of NAR/kg body weight daily for 8 wk p.o. After th

SUBMITTER: Hernandez-Aquino E 

PROVIDER: S-EPMC5487499 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature