Intestinal anti-inflammatory activity of Ground Cherry (Physalis angulata L.) standardized CO₂ phytopharmaceutical preparation.

ABSTRACT:

Aim

To investigate the effects of Ground Cherry (Physalis angulata L.) standardized supercritical CO₂ extract in trinitrobenzenesulphonic acid (TNBS) model of rat intestinal inflammation.

Methods

The animals were divided into groups that received vehicle or P. angulata extract (PACO₂) orally at the doses 25, 50 and 100 mg/kg daily by 5 d before TNBS damage. Protective effects of PACO₂ were assessed by macroscopic analysis, biochemical determinations of the levels of myeloperoxidase (MPO), alkaline phosphatase (ALP), glutathione and cytokines (such as INF-γ, IL-1β, IL-6, IL-10 and TNF-α), gene expression evaluation (including Hsp70, heparanase, NF-κB, mitogen-activated protein kinases (Mapk) 1, 3, 6 and 9, and the mucins genes Mu

SUBMITTER: Almeida Junior LD 

PROVIDER: S-EPMC5487500 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature