A new TK model approach to assess the effect of migration on copper toxicokinetics in inbred populations of the flour beetle, Tribolium castaneum.

ABSTRACT: The aim of the study was to determine the influence of migration on copper (Cu) kinetics of male Tribolium castaneum after 25 generations of exposure for Cu-adapted and non-Cu-adapted inbred lines. Adapted lines were kept on a flour medium contaminated with 1000 mg Cu kg^-1. A medium contaminated with 2000 mg Cu kg^-1 of copper was used during the intoxication phase. Based on our data and literature reports, we introduced a new two-phase four-stage toxicokinetics (TK) model. The intoxication phase was successfully divided into three stages with separate assimilation rate constant (k_a) and elimination rate constant (k_e) values. The influence of migration was examined by comparing k_a and k_e parameters confidence intervals. In no

SUBMITTER: Zmudzki S 

PROVIDER: S-EPMC5487540 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature