Emergence and Evolution of Multidrug-Resistant Klebsiella pneumoniae with both bla_KPC and bla_CTX-M Integrated in the Chromosome.

ABSTRACT: The extended-spectrum-β-lactamase (ESBL)- and Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae represent serious and urgent threats to public health. In a retrospective study of multidrug-resistant K. pneumoniae, we identified three clinical isolates, CN1, CR14, and NY9, carrying both bla_CTX-M and bla_KPC genes. The complete genomes of these three K. pneumoniae isolates were de novo assembled by using both short- and long-read whole-genome sequencing. In CR14 and NY9, bla_CTX-M and bla_KPC were carried on two different plasmids. In contrast, CN1 had one copy of bla_KPC-2 and three copies of bla_CTX-M-15 integrated in the chromosome,

SUBMITTER: Huang W 

PROVIDER: S-EPMC5487645 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature