NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas.

ABSTRACT: Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant Klebsiella pneumoniae ST147 isolate harboring bla_NDM-5 and bla_OXA-181 from a young man who underwent abdominal surgery in India. bla_NDM-5 was located on an IncFII plasmid of ≈90 kb, whereas bla_OXA-181 was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS26 and a "hot-spot region" in the IncFII plasmid.

SUBMITTER: Rojas LJ 

PROVIDER: S-EPMC5487671 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature