Novel Plasmid-Mediated Colistin Resistance Gene <i>mcr-3</i> in <i>Escherichia coli</i>.

ABSTRACT: The mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant Gram-negative bacteria. To date, six slightly different variants of mcr-1, and a second mobile colistin resistance gene, mcr-2, have been reported or annotated in the GenBank database. Here, we characterized a third mobile colistin resistance gene, mcr-3 The gene coexisted with 18 additional resistance determinants in the 261-kb IncHI2-type plasmid pWJ1 from porcine Escherichia colimcr-3 showed 45.0% and 47.0% nucleotide sequence identity to mcr-1 and mcr-2, respectively, while the deduced amino acid sequence of

SUBMITTER: Yin W 

PROVIDER: S-EPMC5487729 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature