NK1.1^- CD4⁺ NKG2D⁺ T cells suppress DSS-induced colitis in mice through production of TGF-β.

ABSTRACT: CD4⁺ NKG2D⁺ T cells are associated with tumour, infection and autoimmune diseases. Some CD4⁺ NKG2D⁺ T cells secrete IFN-γ and TNF-α to promote inflammation, but others produce TGF-β and FasL to facilitate tumour evasion. Here, murine CD4⁺ NKG2D⁺ T cells were further classified into NK1.1^- CD4⁺ NKG2D⁺ and NK1.1⁺ CD4⁺ NKG2D⁺ subpopulations. The frequency of NK1.1^- CD4⁺ NKG2D⁺ cells decreased in inflamed colons, whereas more NK1.1⁺ CD4⁺ NKG2D⁺ cells infiltrated into colons of mice with DSS-induced colitis. NK1.1^- CD4⁺ NKG2D⁺ cells expressed TGF-β and FasL without se

SUBMITTER: Qian X 

PROVIDER: S-EPMC5487917 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature