Differential control of peripheral circadian rhythms by suprachiasmatic-dependent neural signals.
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ABSTRACT:
SUBMITTER: Guo H
PROVIDER: S-EPMC548796 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Publications
Differential control of peripheral circadian rhythms by suprachiasmatic-dependent neural signals.
Guo Hongnian H Brewer Judy McKinley JM Champhekar Ameya A Harris Ruth B S RB Bittman Eric L EL
Proceedings of the National Academy of Sciences of the United States of America 20050214 8
Although dependent on the integrity of a central pacemaker in the suprachiasmatic nucleus of the hypothalamus (SCN), endogenous daily (circadian) rhythms are expressed in a wide variety of peripheral organs. The pathways by which the pacemaker controls the periphery are unclear. Here, we used parabiosis between intact and SCN-lesioned mice to show that nonneural (behavioral or bloodborne) signals are adequate to maintain circadian rhythms of clock gene expression in liver and kidney, but not in ...[more]
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