A Prospective Population Pharmacokinetic Study on Morphine Metabolism in Cancer Patients.

ABSTRACT:

Background

Oral and subcutaneous morphine is widely used for the treatment of cancer-related pain; however, solid pharmacokinetic data on this practice are lacking. Furthermore, it is largely unknown which factors contribute to the variability in clearances of morphine and its metabolites and whether morphine clearance is related to treatment outcome.

Methods

Blood samples from 49 cancer patients treated with oral and/or subcutaneous morphine were prospectively collected and were used to develop a population pharmacokinetic model for morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). The influence of age, gender, renal function and several polymorphisms possibly related to the pharmacokinetics of the three compounds was investigated. In addition, the re

SUBMITTER: Oosten AW 

PROVIDER: S-EPMC5488155 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature