Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells.

ABSTRACT: Influenza A virus (IAV) causes annual epidemics and occasional pandemics, and is one of the best-characterized human RNA viral pathogens¹. However, a physiologically relevant role for the RNA interference (RNAi) suppressor activity of the IAV non-structural protein 1 (NS1), reported over a decade ago², remains unknown³. Plant and insect viruses have evolved diverse virulence proteins to suppress RNAi as their hosts produce virus-derived small interfering RNAs (siRNAs) that direct specific antiviral defence^4-7 by an RNAi mechanism dependent on the slicing activity of Argonaute proteins (AGOs)^8,9. Recent studies have documented induction and suppression of antiviral RNAi in mouse embryonic stem cells and suckling mice^10,11. Ho

SUBMITTER: Li Y 

PROVIDER: S-EPMC5488270 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature