Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes.

ABSTRACT: Macromolecular protein complexes carry out many of the essential functions of cells, and many genetic diseases arise from disrupting the functions of such complexes. Currently, there is great interest in defining the complete set of human protein complexes, but recent published maps lack comprehensive coverage. Here, through the synthesis of over 9,000 published mass spectrometry experiments, we present hu.MAP, the most comprehensive and accurate human protein complex map to date, containing > 4,600 total complexes, > 7,700 proteins, and > 56,000 unique interactions, including thousands of confident protein interactions not identified by the original publications. hu.MAP accurately recapitulates known complexes withheld from the learning procedure, which was optimized with the aid of a new

SUBMITTER: Drew K 

PROVIDER: S-EPMC5488662 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature