Functional proteogenomics reveals biomarkers and therapeutic targets in lymphomas.

ABSTRACT: Identification of biomarkers and therapeutic targets is a critical goal of precision medicine. N-glycoproteins are a particularly attractive class of proteins that constitute potential cancer biomarkers and therapeutic targets for small molecules, antibodies, and cellular therapies. Using mass spectrometry (MS), we generated a compendium of 1,091 N-glycoproteins (from 40 human primary lymphomas and cell lines). Hierarchical clustering revealed distinct subtype signatures that included several subtype-specific biomarkers. Orthogonal immunological studies in 671 primary lymphoma tissue biopsies and 32 lymphoma-derived cell lines corroborated MS data. In anaplastic lymphoma kinase-positive (ALK⁺) anaplastic large cell lymphoma (ALCL), integration of N-glycoproteomics and transcript

SUBMITTER: Rolland DCM 

PROVIDER: S-EPMC5488937 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature