Early Infant Growth Velocity Patterns and Cardiovascular and Metabolic Outcomes in Childhood.

ABSTRACT:

Objective

To evaluate the impact of infant growth on childhood health by examining the associations of detailed longitudinal infant weight velocity patterns with childhood cardiovascular and metabolic outcomes.

Study design

In a population-based prospective cohort study of 4649 children, we used repeated growth measurements at age 0-3 years to derive peak weight velocity (PWV), age at adiposity peak (AGEAP), and body mass index at adiposity peak (BMIAP). At age 6 years, we measured blood pressure, left ventricular mass, and cholesterol, triglyceride, and insulin concentrations and defined children with clusters of risk factors. We assessed associations using 2 multivariable linear regression models.

Results

A 1-SDS-higher infant PWV was associated with higher diastoli

SUBMITTER: Marinkovic T 

PROVIDER: S-EPMC5489080 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature