Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection.

ABSTRACT: Immune cells sense and react to a multitude of factors including both host and microbe-derived signals. Understanding how cells translate these cues into particular cellular behaviors is a complex yet critical area of study. We have previously shown that both neutrophils and macrophages are important for controlling the fish pathogen Streptococcus iniae. Here, we report both host and bacterial determinants leading to the formation of organized macrophage aggregates as part of the host inflammatory response in a subset of infected larvae. Streptococcal capsule was a required signal for aggregate formation. Macrophage aggregation coincided with NFκB activity, and the formation of these aggregates is mediated by leukotriene B4 (LTB4) produced by neutrophils. Depletion, inhibition, or genetic

SUBMITTER: Vincent WJB 

PROVIDER: S-EPMC5489177 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature