Comparison of X-chromosome inactivation patterns in multiple tissues from human females.

ABSTRACT:

Background

X-chromosome inactivation (XCI) is the mechanism by which gene dosage uniformity is achieved between female mammals with two X chromosomes and male mammals with a single X chromosome, and is thought to occur randomly. For molecular genetic testing, accessible tissues (eg blood) are commonly studied, but the relationship with inaccessible tissues (eg brain) is poorly understood. For accessible tissues to be informative for genetic analysis, a high degree of concordance of genetic findings among tissue types is required.

Objective

To determine the relationship among multiple tissues within females at different ages (fetus to 82 years).

Methods

XCI patterns were analysed using the polymorphic androgen receptor (AR) gene assay. DNA was isolated from 26 differen

SUBMITTER: Bittel DC 

PROVIDER: S-EPMC5489244 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature