Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9 to 13 Years.

ABSTRACT: IGF-I is a pivotal hormone in pediatric musculoskeletal development. Although recent data suggest that the role of IGF-I in total body lean mass and total body bone mass accrual may be compromised in children with insulin resistance, cortical bone geometric outcomes have not been studied in this context. Therefore, we explored the influence of insulin resistance on the relationship between IGF-I and cortical bone in children. A secondary aim was to examine the influence of insulin resistance on the lean mass-dependent relationship between IGF-I and cortical bone. Children were otherwise healthy, early adolescent black and white boys and girls (ages 9 to 13 years) and were classified as having high (n = 147) or normal (n = 168) insulin resistance based on the homeostasis model assessment of

SUBMITTER: Kindler JM 

PROVIDER: S-EPMC5489353 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature