Intermittent Aortic Valve Opening and Risk of Thrombosis in Ventricular Assist Device Patients.

ABSTRACT: The current study evaluates quantitatively the impact that intermittent aortic valve (AV) opening has on the thrombogenicity in the aortic arch region for patients under left ventricular assist device (LVAD) therapy. The influence of flow through the AV, opening once every five cardiac cycles, on the flow patterns in the ascending aortic is measured in a patient-derived computed tomography image-based model, after LVAD implantation. The mechanical environment of flowing platelets is investigated, by statistical treatment of outliers in Lagrangian particle tracking, and thrombogenesis metrics (platelet residence times and activation state characterized by shear stress accumulation) are compared for the cases of closed AV versus intermittent AV opening. All hemodynamics metrics are improved

SUBMITTER: Mahr C 

PROVIDER: S-EPMC5489364 | biostudies-literature | 2017 Jul/Aug

REPOSITORIES: biostudies-literature