Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.

ABSTRACT:

Background

International consensus recognises four medulloblastoma molecular subgroups: WNT (MB_WNT), SHH (MB_SHH), group 3 (MB_Grp3), and group 4 (MB_Grp4), each defined by their characteristic genome-wide transcriptomic and DNA methylomic profiles. These subgroups have distinct clinicopathological and molecular features, and underpin current disease subclassification and initial subgroup-directed therapies that are underway in clinical trials. However, substantial biological heterogeneity and differences in survival are apparent within each subgroup, which remain to be resolved. We aimed to investigate whether additional molecular subgroups exist within childhood medulloblastoma and whether these could be used to improve disease subclassifi

SUBMITTER: Schwalbe EC 

PROVIDER: S-EPMC5489698 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature