Stochastic amplification and signaling in enzymatic futile cycles through noise-induced bistability with oscillations.

ABSTRACT: Stochastic effects in biomolecular systems have now been recognized as a major physiologically and evolutionarily important factor in the development and function of many living organisms. Nevertheless, they are often thought of as providing only moderate refinements to the behaviors otherwise predicted by the classical deterministic system description. In this work we show by using both analytical and numerical investigation that at least in one ubiquitous class of (bio)chemical-reaction mechanisms, enzymatic futile cycles, the external noise may induce a bistable oscillatory (dynamic switching) behavior that is both quantitatively and qualitatively different from what is predicted or possible deterministically. We further demonstrate that the noise required to produce these distinct prop

SUBMITTER: Samoilov M 

PROVIDER: S-EPMC548975 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature