Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC5489757 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nature cell biology 20170213 3
Progression of mammalian cells through the G1 and S phases of the cell cycle is driven by the D-type and E-type cyclins. According to the current models, at least one of these cyclin families must be present to allow cell proliferation. Here, we show that several cell types can proliferate in the absence of all G1 cyclins. However, following ablation of G1 cyclins, embryonic stem (ES) cells attenuated their pluripotent characteristics, with the majority of cells acquiring the trophectodermal cel ...[more]