Ontology highlight
ABSTRACT:
SUBMITTER: Kawakami Y
PROVIDER: S-EPMC548985 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Kawakami Yasuhiko Y Tsuda Masanao M Takahashi Shigeru S Taniguchi Noboru N Esteban Concepción Rodríguez CR Zemmyo Michihisa M Furumatsu Takayuki T Lotz Martin M Izpisúa Belmonte Juan Carlos JC Asahara Hiroshi H
Proceedings of the National Academy of Sciences of the United States of America 20050207 7
Chondrogenesis is a multistep pathway in which multipotential mesenchymal stem cells (MSC) differentiate into chondrocytes. The transcription factor Sox9 (SRY-related high mobility group-Box gene 9) regulates chondrocyte differentiation and cartilage-specific expression of genes, such as Col2a1 (collagen type II alpha1). However, Sox9 expression is detected not only in chondrogenic tissue but also in nonchondrogenic tissues, suggesting the existence of a molecular partner(s) required for Sox9 to ...[more]