Interactome analysis of gene expression profiles of cervical cancer reveals dysregulated mitotic gene clusters.

ABSTRACT: Cervical cancer is the second most common malignancy in women worldwide. HPV infections are the leading cause of cervical cancer. Although progress has been made in understanding cervical cancer, knowledge of oncogenic gene clusters that participate in squamous-cell mitosis is still lacking. We performed a computational analysis with qRT-PCR validation of gene expression profiles of cervical cancer tissues. Genes involved in muscle contraction and development were downregulated in cervical cancer tissues, suggesting decreased muscle function in cervical cancer. Among the genes that were upregulated in cervical cancer tissues, several groups of genes were found to interact with each other and synergistically participate in multiple stages of mitosis including DNA replication, cell cycle pro

SUBMITTER: Cheng J 

PROVIDER: S-EPMC5489904 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature