Chronic intermittent hypoxia decreases pulmonary clearance of ^99mTc-labelled particulate matter in mice.

ABSTRACT:

Background

Obstructive sleep apnea-hypopnea syndrome (OSAHS) could cause systematic inflammation including pulmonary inflammatory response, whereas the influence of OSAHS in pulmonary clearance ability remains unknown. The main pathophysiological feature of OSAHS is chronic intermittent hypoxia (CIH). The goal of this study is to clarify the airway clearance of particulate matter (PM) in CIH mice, and to explore the potential mechanism.

Methods

Balb/c mice were divided into a CIH group and a control group, exposed to intermittent hypoxia and air chamber, respectively. A radioactive probe, ^99mTc labeled PM, was endotracheally inserted into the mice at 10 mg/kg, with a starting dose of 800 μCi. The change of radioactive dose reserved in the lung was observed using s

SUBMITTER: Fu C 

PROVIDER: S-EPMC5489905 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature