Prevalence of sexual dimorphism in mammalian phenotypic traits.

ABSTRACT: The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.

SUBMITTER: Karp NA 

PROVIDER: S-EPMC5490203 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature