Association of BUD13 polymorphisms with metabolic syndrome in Chinese population: a case-control study.

ABSTRACT:

Background

BUD13 homolog (BUD13), one of submits of the retention and splicing complex, was identified in yeast as a splicing factor that affected nuclear pre-mRNA retention. While more and more studies demonstrated that BUD13 played a potential role in the pathogenesis of metabolic syndrome (MetS). This objective was to reassess whether novel locus of BUD13 were linked to MetS and individual complements in the northeast of China.

Methods

A total of 3850 individuals were recruited in this case-control study, including 1813 MetS cases and 2037 healthy controls. The diagnostic criteria was according to the International Diabetes Federation (IDF). Metabolic complements such as waist circumference (WC), triglyceride, high-density lipoprotein cholesterol (HDL-C), systolic and dia

SUBMITTER: Zhang L 

PROVIDER: S-EPMC5490231 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature