Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization.

ABSTRACT:

Background

The ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) proteins are a family of metalloproteases with sequence similarity to the ADAM proteases, that contain the thrombospondin type 1 sequence repeat motifs (TSRs) common to extracellular matrix proteins. ADAMTS proteins have recently gained attention with the discovery of their role in a variety of diseases, including tissue and blood disorders, cancer, osteoarthritis, Alzheimer's and the genetic syndromes Weill-Marchesani syndrome (ADAMTS10), thrombotic thrombocytopenic purpura (ADAMTS13), and Ehlers-Danlos syndrome type VIIC (ADAMTS2) in humans and belted white-spotting mutation in mice (ADAMTS20).

Results

Phylogenetic analysis and comparison of the exon/intron organization of vertebrate

SUBMITTER: Nicholson AC 

PROVIDER: S-EPMC549037 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature