PKC in Regenerative Therapy: New Insights for Old Targets.

ABSTRACT: Effective therapies for chronic or non-healing wounds are still lacking. These tissue insults often result in severe clinical complications (i.e., infections and/or amputation) and sometimes lead to patient death. Accordingly, several research groups have focused their efforts in finding innovative and powerful therapeutic strategies to overcome these issues. On the basis of these considerations, the comprehension of the molecular cascades behind these pathological conditions could allow the identification of molecules against chronic wounds. In this context, the regulation of the Protein Kinase C (PKC) cascade has gained relevance in the prevention and/or reparation of tissue damages. This class of phosphorylating enzymes has already been considered for different physiological and patholo

SUBMITTER: Rui M 

PROVIDER: S-EPMC5490403 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature