A Short-Term Biological Indicator for Long-Term Kidney Damage after Radionuclide Therapy in Mice.

ABSTRACT: Folate receptor (FR)-targeted radionuclide therapy using folate radioconjugates is of interest due to the expression of the FR in a variety of tumor types. The high renal accumulation of radiofolates presents, however, a risk of radionephropathy. A potential option to address this challenge would be to use radioprotectants, such as amifostine. Methods for early detection of kidney damage that-in this case-cannot be predicted based on dose estimations, would facilitate the development of novel therapies. The aim of this study was, therefore, to assess potentially changing levels of plasma and urine biomarkers and to determine DNA damage at an early stage after radiofolate application. The identification of an early indicator for renal damage in mice would be useful since histological change

SUBMITTER: Pellegrini G 

PROVIDER: S-EPMC5490414 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature