Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.

ABSTRACT: While antibody titers and neutralization are considered the gold standard for the selection of successful vaccines, these parameters are often inadequate predictors of protective immunity. As antibodies mediate an array of extra-neutralizing Fc functions, when neutralization fails to predict protection, investigating Fc-mediated activity may help identify immunological correlates and mechanism(s) of humoral protection. Here, we used an integrative approach termed Systems Serology to analyze relationships among humoral responses elicited in four HIV vaccine trials. Each vaccine regimen induced a unique humoral "Fc fingerprint." Moreover, analysis of case:control data from the first moderately protective HIV vaccine trial, RV144, pointed to mechanistic insights into immune complex compositio

SUBMITTER: Chung AW 

PROVIDER: S-EPMC5490491 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature