Influence of protein fold stability on immunogenicity and its implications for vaccine design.

ABSTRACT:

Introduction

In modern vaccinology and immunotherapy, recombinant proteins more and more replace whole organisms to induce protective or curative immune responses. Structural stability of proteins is of crucial importance for efficient presentation of antigenic peptides on MHC, which plays a decisive role for triggering strong immune reactions. Areas covered: In this review, we discuss structural stability as a key factor for modulating the potency of recombinant vaccines and its importance for antigen proteolysis, presentation, and stimulation of B and T cells. Moreover, the impact of fold stability on downstream events determining the differentiation of T cells into effector cells is reviewed. We summarize studies investigating the impact of protein fold stability on the outcome

SUBMITTER: Scheiblhofer S 

PROVIDER: S-EPMC5490637 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature