Hard to look on the bright side: neural correlates of impaired emotion regulation in depressed youth.

ABSTRACT: The cognitive regulation of emotion is impaired in major depressive disorder and has been linked to an imbalance of pre-frontal-subcortical brain activity. Despite suggestions that this relationship represents a neurodevelopmental marker of depression, few studies have examined the neural correlates of emotion regulation in depressed youth. We combined a 'cognitive reappraisal' paradigm with functional magnetic resonance imaging to study the neural correlates of emotional regulation in a large sample of non-medicated depressed adolescents and young adults (n = 53) and healthy controls (n = 64). As compared with healthy controls, young people with depression were less able to reduce negative affect during reappraisal, which corresponded to blunted modulation of amygdala activity. While in h

SUBMITTER: Stephanou K 

PROVIDER: S-EPMC5490679 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature