Domain Stability in Biomimetic Membranes Driven by Lipid Polyunsaturation.

ABSTRACT: Biological membranes contain a broad variety of lipid species whose individual physicochemical properties and collective interactions ultimately determine membrane organization. A key aspect of the organization of cellular membranes is their lateral subdivision into domains of distinct structure and composition. The most widely studied membrane domains are lipid rafts, which are the biological manifestations of liquid-ordered phases that form in sterol-containing membranes. Detailed studies of biomimetic membrane mixtures have yielded wide-ranging insights into the physical principles behind lipid rafts; however, these simplified models do not fully capture the diversity and complexity of the mammalian lipidome, most notably in their exclusion of polyunsaturated lipids. Here, we assess the

SUBMITTER: Lin X 

PROVIDER: S-EPMC5490800 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature